Browse Projects

Autophagy in Pancreatic Cell lines
Project Start Date: Sep 2015
Project Status: Published
Lab: Maria New - Tooze Lab
Keywords: Autophagy, Pancreatic Cancer
Libraries: Full Genome 384, Full Genome 1536, Cherry Pick Deconvolution - KP4 Autophagy, Maria Tim Autophagy Cherry Pick Hits
CellLines: KP-4, PK1

G2 checkpoint mechanisms and the characterisation of biomarkers for the stratification of PKCe inhibitor-sensitive tumours
Project Start Date: Nov 2013
Project Status: Published
Lab: Katharina Deiss - Parker Lab
Keywords: G2
Libraries: Full Genome 384, E3 Ligase 384, Custom Order Katharina (384)
CellLines: RPE1, U2OS Cas9 C5

Synthetic lethality screen with Cdc7 inhibitor
Project Start Date: Mar 2012
Project Status: Primary Screen
Lab: Flo Chan - CRT Lab
Keywords: Cdc7 inhibitor, Viability
Libraries: Full Genome 384
CellLines: MCF-7, A-549

Identification of novel components of the TGFß pathway
Project Start Date: May 2012
Project Status: Published
Lab: Debbie Das - Hill Lab
Keywords: Smad2/3, TGFB, TGFbeta, TGFß
Libraries: Full Genome 384, Phosphatase Library - (384 well), Custom Order - TGFB hits, CP, Custom Order - Daniel, Full Genome 1536
CellLines: HaCaT

Identification of metabolic targets that are essential for cancer survival under normoxic and hypoxic conditions using breast and prostate cancer cell lines
Project Start Date: March 2012
Project Status: Published
Lab: Barrie Peck - Schulze Lab
Keywords: Hypoxia, Metabolism, Normoxia, Viability
Libraries: Custom Order - Barrie
CellLines: BT-20, BT-549, MCF-7, MCF-10A, MDA-MB-231, MDA-MB-468, SK-BR-3, T-47D, RPE1, DU-145, PC-3, LNCaP

Identification of genes mediating hypoxia sensitivity and resistence in Renal Clear Cell carcinoma cells
Project Start Date: Jan 2011
Project Status: Published
Lab: Claudio Santos - Swanton Lab
Keywords: Hypoxia, Kidney cancer, Viability
Libraries: Kinome Library 384 (2011)
CellLines: A498, 786-O

Targeting PTEN inactivation: A tumour suppressor loss synthetic lethal siRNA screen
Project Start Date: Dec 2010
Project Status: Validating Hits
Lab: George Vlachogiannis - Downward Lab
Keywords: PTEN, Viability
Libraries: Combined Kinase, GPCR, Druggable, Full Genome 96, Custom Order - George, Cherry Pick - George
CellLines: MCF-10A, SK-BR-3, AU-565, HS578T, MDA-MB-231, CAMA-1, HCC-38, HCC-1187, HCC-1806, HCC-1395, HCC-1569, HCC-1937, MDA-MB-157, MDA-MB-468, MDA-MB-436, BT-549, 184B5, MCF-12A

Identification of novel regulators of cytokinesis in human cells
Project Start Date: Feb 2009
Project Status: Published
Lab: Ram Sundaramoorthy - Petronczki Lab
Keywords: Cytokinesis
Libraries: RAM Nuclear Proteins
CellLines: HeLa iCas9 gRNA TRF2

Identification of metabolic enzymes essential for proliferation and survival of breast cancer cells
Project Start Date: Feb 2009
Project Status: Published
Lab: Franzi Baenke - Schulze Lab
Keywords: Breast Cancer, Metabolism, Viability
Libraries: Glucose Metabolism Custom Franzi
CellLines: BT-549, MCF-7, MCF-10A, T-47D, HS578T, MDA-MB-231, SK-BR-3, 184B5, BT-20, MDA-MB-436, MCF-12A, ZR-75-1, AU-565, HCC-38, HCC-1806, HCC-1954, HME1

Determinants of erlotinib resistance in lung cancer
Project Start Date: Oct 2009
Project Status: Published
Lab: Elza De Bruin - Downward Lab
Keywords: Erlotinib, Lung Cancer, Viability
Libraries: Full Genome 384, Cherry Pick - Elza Pick, Human miRNA Mimics 384, Human miRNA Inhibitors 384, Cherry Pick- Elza hits, Cherry Pick - Elza, Custom Order - Elza EGFR Hits, Custom Order - Elza
CellLines: PC-9, EKVX, H1650, H1975, H4006, H3255, HCC-78, SK-MES-1

Functional genomic identification of mediators of everolimus sensitivity in kidney cancer cell lines
Project Start Date: July 2009
Project Status: Published
Lab: Marco Gerlinger - Swanton Lab
Keywords: Everolimus, Kidney cancer, Viability
Hits: NM_001042423 - MCT4 Identified to impair RCC cell viability.
Libraries: Full Genome 384, Cherry Pick - Marco Pick
CellLines: RCC4, A498, 786-O

Molecular mechanisms of PKC-induced activation of ADAM proteases
Project Start Date: Mar 2009
Project Status: Published
Lab: Marie Kveiborg - Parker Lab
Keywords: ADAM proteases, HT1080, PKC
Libraries: Full Genome 96, Cherry Pick
CellLines: SJSA1

Characterisation of genomic instability-specific survival pathways
Project Start Date: Mar 2009
Project Status: Published
Lab: Alvin Lee - Swanton Lab
Keywords: CIN, MAD2
Libraries: Full Genome 96, Cherry Pick - Alvin hits
CellLines: HCT116

Combining split-TEV and RNAi screening techniques to dissect the Hippo pathway
Project Start Date: Sep 2008
Project Status: Published
Lab: Michael Wehr - Tapon Lab
Keywords: Hippo signalling
Libraries: Ambion Genome Library
CellLines: S2R+

Identification of novel molecules involved in autophagy
Project Start Date: Apr 2008
Project Status: Published
Lab: Nicole McKnight - Tooze Lab
Keywords: Amino acid deprivation, Autophagosome, Autophagy
Hits: NM_016628 - Amino acid starvation-induced autophagy requires WAC
NM_032547 - Amino acid starvation-induced autophagy requires SCOC
Libraries: Full Genome 96, Cherry Pick - Nicole Hits
CellLines: HEK 293

Identification of regulators of Hippo Signaling
Project Start Date: Oct 2007
Project Status: Published
Lab: Filipe Josue - Tapon Lab
Keywords: Hippo signaling
Libraries: Ambion Genome Library
CellLines: S2R+