HTS Screening Database

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News

Apr 2019Publication: MDH1 and MPP7 Regulate Autophagy in Pancreatic Ductal Adenocarcinoma. New et al., 2019 for the Autophagy in Pancreatic Cell lines Project
Apr 2019Publication: A genome-wide RNAi screen identifies the SMC5/6 complex as a non-redundant regulator of a Topo2a-dependent G2 arrest. Deiss et al., for the G2 checkpoint mechanisms and the characterisation of biomarkers for the stratification of PKCe inhibitor-sensitive tumours Project
Nov 2018Publication: The Dynamics of TGF-β Signaling Are Dictated by Receptor Trafficking via the ESCRT Machinery. Miller et al., 2018 for the Identification of novel components of the TGFß pathway Project
Oct 2018Publication: The glutathione redox system is essential to prevent ferroptosis caused by impaired lipid metabolism in clear cell renal cell carcinoma. Miess et al., 2019 for the Identification of genes mediating hypoxia sensitivity and resistence in Renal Clear Cell carcinoma cells Project
Feb 2017Enzyme/Inhibitor screen complete for Edgar Deu's Chemical Biology Approaches to Malaria Laboratory
Aug 2016HTS database fully migrated to the Crick lab
Jul 2016HTS lab moves into to the new Crick lab
Jan 2016Publication: Knockout of the PKN Family of Rho Effector Kinases Reveals a Non-redundant Role for PKN2 in Developmental Mesoderm Expansion. Quétier et al., 2016. Cell Rep 14(3):440-8
Sept 2015Completed Genome Wide Screen in KP4 Pancreatic Cell Line for the Autophagy in Pancreatic Cell lines Project
May 2015Publication: Functional screening identifies MCT4 as a key regulator of breast cancer cell metabolism and survival. Baenke et al., 2015. J Pathol. 2015 May 12. doi: 10.1002 for the Identification of metabolic enzymes essential for proliferation and survival of breast cancer cells Project
Jan 2015Publication: Acetyl-CoA synthetase 2 promotes acetate utilization and maintains cancer cell growth under metabolic stress. Cancer Cell. 2015 27:57-71. for the Identification of metabolic targets that are essential for cancer survival under normoxic and hypoxic conditions using breast and prostate cancer cell lines Project
Jul 2014Publication: Ccdc13 is a novel human centriolar satellite protein required for ciliogenesis and genome stability. J Cell Sci. 2014;127(Pt 13):2910-9. for the Characterisation of genomic instability-specific survival pathways Project
Sep 2014September 2014 The HTS lab completes the first genome-wide siRNA screens in the high density 1536-well plate format
Mar 2014Completed Genome Wide Screen in RPE1 cell line and analysed data available for the G2 checkpoint mechanisms and the characterisation of biomarkers for the stratification of PKCe inhibitor-sensitive tumours Project
Dec 2013Currently reading results for genome wide screen in RPE1 cell line. for the G2 checkpoint mechanisms and the characterisation of biomarkers for the stratification of PKCe inhibitor-sensitive tumours Project
Oct 2013Database Publication: HTS-DB: an online resource to publish and query data from functional genomics high-throughput siRNA screening projects. <a href="http://database.oxfordjournals.org/content/2013/bat072.abstract?keytype=ref&ijkey=o9CJZJR0mVoyRUM" target="_blank">Saunders et al., Database 2013</a>
January 2013Publication: Salt-inducible kinases regulate growth through the Hippo signalling pathway in Drosophila. Wehr et al, Nature Cell Biology 2013 for the Combining split-TEV and RNAi screening techniques to dissect the Hippo pathway Project
October 2012Genome-wide screen just completed and analysed in HaCat cell line for the Identification of novel components of the TGFß pathway Project
June 2012Publication: Genome-wide RNA interference analysis of renal carcinoma survival regulators identifies MCT4 as a Warburg effect metabolic target. Gerlinger et al. 2012. for the Functional genomic identification of mediators of everolimus sensitivity in kidney cancer cell lines Project