Please reference the following paper if you use this database for your work:
HTS-DB: an online resource to publish and query data from functional genomics high-throughput siRNA screening projects.
Saunders et al., Database 2013.
Francis Crick Insitute siRNA screening publications (most recent first)
- The essential host genome for Cryptosporidium survival exposes metabolic dependencies that can be leveraged for treatment
N Bishara Marzook, Ok-Ryul Song, Lotta Baumgärtel, Netanya Bernitz, Tapoka T Mkandawire, Lucy C Watson, Vanessa Nunes, Scott Warchal, James I MacRae, Michael Howell, Adam Sateriale
Cell - The cis-regulatory logic integrating spatial and temporal patterning in the vertebrate neural tube
Isabel Zhang, Giulia L M Boezio, Jake Cornwall-Scoones, Thomas Frith, Elizabeth Finnie, Junyi Luo, Ming Jiang, Michael Howell, Robin Lovell-Badge, Andreas Sagner, James Briscoe, M Joaquina Delás
Developmental Cell - The DNA replication checkpoint prevents PCNA/RFC depletion to protect forks from HLTF-induced collapse in human cells
Agostina P Bertolin, Berta Canal, Mona Yekezare, Anne Early, Jingkun Zeng, Rachael Instrell, Michael Howell, John F X Diffley
Molecular Cell - ATG9A and ARFIP2 cooperate to control PI4P levels for lysosomal repair
Stefano De Tito, Eugenia Almacellas, Daniel Dai Yu, Emily Millard, Wenxin Zhang, Cecilia de Heus, Christophe Queval, Javier H Hervás, Enrica Pellegrino, Ioanna Panagi, Ditte Fogde, Teresa L M Thurston, Judith Klumperman, Maximiliano Gutierrez, Sharon A Tooze
Developmental Cell - Post-gastrulation amnioids as a stem cell-derived model of human extra-embryonic development
Borzo Gharibi, Oliver C K Inge, Irene Rodriguez-Hernandez, Paul C Driscoll, Christelle Dubois, Ming Jiang, Michael Howell, J Mark Skehel, James I Macrae, Silvia D M Santos
Cell - GRA12 is a common virulence factor across Toxoplasma gondii strains and mouse subspecies
Francesca Torelli, Simon Butterworth, Eloise Lockyer, Ana N Matias, Franziska Hildebrandt, Ok-Ryul Song, Jennifer Pearson-Farr, Moritz Treeck
Nature Communications - Systematic genetic perturbation reveals principles underpinning robustness of the epigenetic regulatory network
Thomas Stuart Wilson, Roberta Noberini, Eirini Moysidou, Ifeyinwa Ojukwu, Marta Milan, Ming Jiang, Gavin Kelly, Michael Howell, Tiziana Bonaldi, Paola Scaffidi
Nucleic Acid Research - High-Throughput Drug Screening in a Cellular Model of KRAS-Driven Arteriovenous Malformations
Fanourios Michailidis, Davide Zecchin, Mohammad Rabii, Ignacio Del Valle Torres, Aimie Sauvadet, Ming Jiang, Michael Howell, Dale Bryant, Satyamaanasa Polubothu, Veronica A Kinsler
Journal of Investigative Dermatology - Caspase cleavage of influenza A virus M2 disrupts M2-LC3 interaction and regulates virion production
Carmen Figueras-Novoa, Masato Akutsu, Daichi Murata, Anne Weston, Ming Jiang, Beatriz Montaner, Christelle Dubois, Avinash Shenoy, Rupert Beale
EMBO Reports - TRACERx analysis identifies a role for FAT1 in regulating chromosomal instability and whole-genome doubling via Hippo signalling
Wei-Ting Lu, Lykourgos-Panagiotis Zalmas, Chris Bailey, James R M Black, Carlos Martinez-Ruiz, Oriol Pich, Francisco Gimeno-Valiente, Ieva Usaite, Alastair Magness, Kerstin Thol, Thomas A Webber, Ming Jiang, Rebecca E Saunders, Yun-Hsin Liu, Dhruva Biswas, Esther O Ige, Birgit Aerne, Eva Grönroos, Subramanian Venkatesan, Georgia Stavrou, Takahiro Karasaki, Maise Al Bakir, Matthew Renshaw, Hang Xu, Deborah Schneider-Luftman, Natasha Sharma, Laura Tovini; TRACERx Consortium; Mariam Jamal-Hanjani, Sarah E McClelland, Kevin Litchfield, Nicolai J Birkbak, Michael Howell, Nicolas Tapon, Kasper Fugger, Nicholas McGranahan, Jiri Bartek, Nnennaya Kanu, Charles Swanton
Nature Cell Biology - Antibacterial activity of Au(I), Pt(II), and Ir(III) biotin conjugates prepared by the iClick reaction: influence of the metal coordination sphere on the biological activity
Dominik Moreth, Lars Stevens-Cullinane, Thomas W Rees, Victoria V L Müller, Adrien Pasquier, Ok-Ryul Song, Scott Warchal, Michael Howell, Jeannine Hess, Ulrich Schatzschneider
Journal of Biological Inorganic Chemistry - CARD14 signalosome formation is associated with its endosomal relocation and mTORC1-induced keratinocyte proliferation
Paul A O'Sullivan, Aigerim Aidarova, Inna S Afonina, Joan Manils, Teresa L M Thurston, Rachael Instrell, Michael Howell, Stefan Boeing, Sashini Ranawana, Melanie B Herpels, Riwia Chetian, Matilda Bassa, Helen Flynn, David Frith, Ambrosius P Snijders, Ashleigh Howes, Rudi Beyaert, Anne M Bowcock, Steven C Ley
Biochemical Journal - Increased dosage of DYRK1A leads to congenital heart defects in a mouse model of Down syndrome
Eva Lana-Elola, Rifdat Aoidi, Miriam Llorian, Dorota Gibbins, Callan Buechsenschuetz, Claudio Bussi, Helen Flynn, Tegan Gilmore, Sheona Watson-Scales, Marie Haugsten Hansen, Darryl Hayward, Ok-Ryul Song, Véronique Brault, Yann Herault, Emmanuel Deau, Laurent Meijer, Ambrosius P Snijders, Maximiliano G Gutierrez, Elizabeth M C Fisher, Victor L J Tybulewicz
Science Translational Medicine - A heterotrimeric complex of Toxoplasma proteins promotes parasite survival in interferon gamma-stimulated human cells
Eloise J Lockyer, Francesca Torelli, Simon Butterworth, Ok-Ryul Song, Steven Howell, Anne Weston, Philip East, Moritz Treeck
PLoS Biology - Independent SARS-CoV-2 staff testing protected academic and health-care institutions in northwest London
Chris Bailey, Theo Sanderson, Hermaleigh Townsley, Jacki Goldman, James R M Black, George Young, Robert Goldstone, Ashley S Fowler, Sophia Ward, Deborah J Jackson, Laura Cubitt, Vicky Dearing, Olga O'Neil, Marg Crawford, Daniel Snell, Makis Finadis, Amelia Edwards, Jimena Perez-Lloret, Joshua Gahir, Edward J Carr, Andy Riddell, Jim Aitken, Karen Ambrose, Chelsea Sawyer, Nicola O'Reilly, Simon Caidan, Mary Y Wu, Philip A Walker, Steve Hindmarsh, Michael Howell, Andrew Jordan, James Fleming, Catherine Houlihan, Eleni Nastouli, Rachel Moores, Desmond Hsu, Padmasayee Papineni, Tumena Corrah, Richard Gilson, James MacRae, Michael Hubank, Nicholas Van As, Samra Turajlic, Rupert Beale, Marcel Levi; Crick COVID-Consortium; Sam Barrell, Bryan Williams, Steve Gamblin, Jerome Nicod, Sonia Gandhi, David L V Bauer, Emma C Wall, Charles Swanton
The Lancet - Sotrovimab restores neutralization against current Omicron subvariants in patients with blood cancer
Mary Y Wu, Scott T C Shepherd, Annika Fendler, Edward J Carr, Lewis Au, Ruth Harvey, Giulia Dowgier, Agnieszka Hobbs, Lou S Herman, Martina Ragno, Lorin Adams, Andreas M Schmitt, Zayd Tippu, Benjamin Shum, Sheima Farag, Aljosja Rogiers, Nicola O'Reilly, Philip Bawumia, Callie Smith, Eleanor Carlyle, Kim Edmonds, Lyra Del Rosario, Karla Lingard, Mary Mangwende, Lucy Holt, Hamid Ahmod, Justine Korteweg, Tara Foley, Taja Barber, Stephanie Hepworth, Andrea Emslie-Henry, Niamh Caulfield-Lynch, Fiona Byrne, Daqi Deng, Bryan Williams, Michael Brown, Simon Caidan, Mike Gavrielides, James I MacRae, Gavin Kelly, Kema Peat, Denise Kelly, Aida Murra, Kayleigh Kelly, Molly O'Flaherty, Sanjay Popat, Nadia Yousaf, Shaman Jhanji, Kate Tatham, David Cunningham, Nicholas Van As, Kate Young, Andrew J S Furness, Lisa Pickering, Rupert Beale, Charles Swanton, Sonia Gandhi, Steve Gamblin, David L V Bauer, George Kassiotis, Michael Howell, Susanna Walker, Emma Nicholson, James Larkin, Emma C Wall, Samra Turajlic; CAPTURE consortium
Cancer Cell - Functional immune responses against SARS-CoV-2 variants of concern after fourth COVID-19 vaccine dose or infection in patients with blood cancer
Annika Fendler, Scott T C Shepherd, Lewis Au, Mary Wu, Ruth Harvey, Katalin A Wilkinson, Andreas M Schmitt, Zayd Tippu, Benjamin Shum, Sheima Farag, Aljosja Rogiers, Eleanor Carlyle, Kim Edmonds, Lyra Del Rosario, Karla Lingard, Mary Mangwende, Lucy Holt, Hamid Ahmod, Justine Korteweg, Tara Foley, Taja Barber, Andrea Emslie-Henry, Niamh Caulfield-Lynch, Fiona Byrne, Daqi Deng, Svend Kjaer, Ok-Ryul Song, Christophe J Queval, Caitlin Kavanagh, Emma C Wall, Edward J Carr, Simon Caidan, Mike Gavrielides, James I MacRae, Gavin Kelly, Kema Peat, Denise Kelly, Aida Murra, Kayleigh Kelly, Molly O'Flaherty, Robyn L Shea, Gail Gardner, Darren Murray, Sanjay Popat, Nadia Yousaf, Shaman Jhanji, Kate Tatham, David Cunningham, Nicholas Van As, Kate Young, Andrew J S Furness, Lisa Pickering, Rupert Beale, Charles Swanton, Sonia Gandhi, Steve Gamblin, David L V Bauer, George Kassiotis, Michael Howell, Emma Nicholson, Susanna Walker, Robert J Wilkinson, James Larkin, Samra Turajlic
Cell Reports Medicine - WHO's Therapeutics and COVID-19 Living Guideline on mAbs needs to be reassessed
Mary Y Wu, Edward J Carr, Ruth Harvey, Harriet V Mears, Svend Kjaer, Hermaleigh Townsley, Agnieszka Hobbs, Martina Ragno, Lou S Herman, Lorin Adams, Steve Gamblin, Michael Howell, Rupert Beale, Michael Brown, Bryan Williams, Sonia Gandhi, Charles Swanton, Emma C Wall, David L V Bauer
The Lancet - Antibody correlates of protection from SARS-CoV-2 reinfection prior to vaccination: A nested case-control within the SIREN study
Ana Atti, Ferdinando Insalata, Edward J Carr, Ashley D Otter, Javier Castillo-Olivares, Mary Wu, Ruth Harvey, Michael Howell, Andrew Chan, Jonathan Lyall, Nigel Temperton, Diego Cantoni, Kelly da Costa, Angalee Nadesalingam, Andrew Taylor-Kerr, Nipunadi Hettiarachchi, Caio Tranquillini, Jacqueline Hewson, Michelle J Cole, Sarah Foulkes, Katie Munro, Edward J M Monk, Iain D Milligan, Ezra Linley, Meera A Chand, Colin S Brown, Jasmin Islam, Amanda Semper, Andre Charlett, Jonathan L Heeney, Rupert Beale, Maria Zambon, Susan Hopkins, Tim Brooks, Victoria Hall; SIREN Study Group and the Crick COVID Immunity Pipeline Consortium
Journal of Infection - SARS-CoV-2 S2-targeted vaccination elicits broadly neutralizing antibodies
Kevin W Ng, Nikhil Faulkner, Katja Finsterbusch, Mary Wu, Ruth Harvey, Saira Hussain, Maria Greco, Yafei Liu, Svend Kjaer, Charles Swanton, Sonia Gandhi, Rupert Beale, Steve J Gamblin, Peter Cherepanov, John McCauley, Rodney Daniels, Michael Howell, Hisashi Arase, Andreas Wack, David L V Bauer, George Kassiotis
Science Translational Medicine - USP25 promotes pathological HIF-1-driven metabolic reprogramming and is a potential therapeutic target in pancreatic cancer
Jessica K Nelson, May Zaw Thin, Theodore Evan, Steven Howell, Mary Wu, Bruna Almeida, Nathalie Legrave, Duco S Koenis, Gabriela Koifman, Yoichiro Sugimoto, Miriam Llorian Sopena, James MacRae, Emma Nye, Michael Howell, Ambrosius P Snijders, Andreas Prachalias, Yoh Zen, Debashis Sarker, Axel Behrens
Nature Communications - Microbial communities form rich extracellular metabolomes that foster metabolic interactions and promote drug tolerance
Jason S L Yu, Clara Correia-Melo, Francisco Zorrilla, Lucia Herrera-Dominguez, Mary Y Wu, Johannes Hartl, Kate Campbell, Sonja Blasche, Marco Kreidl, Anna-Sophia Egger, Christoph B Messner, Vadim Demichev, Anja Freiwald, Michael Mülleder, Michael Howell, Judith Berman, Kiran R Patil, Mohammad Tauqeer Alam, Markus Ralser
Nature Microbiology - A network of transcription factors governs the dynamics of NODAL/Activin transcriptional responses
Davide M Coda, Harshil Patel, Ilaria Gori, Tessa E Gaarenstroom, Ok-Ryul Song, Michael Howell, Caroline S Hill
Journal of Cell Science - Functional antibody and T cell immunity following SARS-CoV-2 infection, including by variants of concern, in patients with cancer: the CAPTURE study
Annika Fendler, Lewis Au, Scott T C Shepherd, Fiona Byrne, Maddalena Cerrone, Laura Amanda Boos, Karolina Rzeniewicz, William Gordon, Benjamin Shum, Camille L Gerard, Barry Ward, Wenyi Xie, Andreas M Schmitt, Nalinie Joharatnam-Hogan, Georgina H Cornish, Martin Pule, Leila Mekkaoui, Kevin W Ng, Eleanor Carlyle, Kim Edmonds, Lyra Del Rosario, Sarah Sarker, Karla Lingard, Mary Mangwende, Lucy Holt, Hamid Ahmod, Richard Stone, Camila Gomes, Helen R Flynn, Ana Agua-Doce, Philip Hobson, Simon Caidan, Michael Howell, Mary Wu, Robert Goldstone, Margaret Crawford, Laura Cubitt, Harshil Patel, Mike Gavrielides, Emma Nye, Ambrosius P Snijders, James I MacRae, Jerome Nicod, Firza Gronthoud, Robyn L Shea, Christina Messiou, David Cunningham, Ian Chau, Naureen Starling, Nicholas Turner, Liam Welsh, Nicholas van As, Robin L Jones, Joanne Droney, Susana Banerjee, Kate C Tatham, Shaman Jhanji, Mary O'Brien, Olivia Curtis, Kevin Harrington, Shreerang Bhide, Jessica Bazin, Anna Robinson, Clemency Stephenson, Tim Slattery, Yasir Khan, Zayd Tippu, Isla Leslie, Spyridon Gennatas, Alicia Okines, Alison Reid, Kate Young, Andrew J S Furness, Lisa Pickering, Sonia Gandhi, Steve Gamblin, Charles Swanton; Crick COVID- Consortium; Emma Nicholson, Sacheen Kumar, Nadia Yousaf, Katalin A Wilkinson, Anthony Swerdlow, Ruth Harvey, George Kassiotis, James Larkin, Robert J Wilkinson, Samra Turajlic; CAPTURE consortium
Nature Cancer - Omicron neutralising antibodies after third COVID-19 vaccine dose in patients with cancer
Annika Fendler, Scott T C Shepherd, Lewis Au, Mary Wu, Ruth Harvey, Andreas M Schmitt, Zayd Tippu, Benjamin Shum, Sheima Farag, Aljosja Rogiers, Eleanor Carlyle, Kim Edmonds, Lyra Del Rosario, Karla Lingard, Mary Mangwende, Lucy Holt, Hamid Ahmod, Justine Korteweg, Tara Foley, Taja Barber, Andrea Emslie-Henry, Niamh Caulfield-Lynch, Fiona Byrne, Daqi Deng, Svend Kjaer, Ok-Ryul Song, Christophe Queval, Caitlin Kavanagh, Emma C Wall, Edward J Carr, Simon Caidan, Mike Gavrielides, James I MacRae, Gavin Kelly, Kema Peat, Denise Kelly, Aida Murra, Kayleigh Kelly, Molly O'Flaherty, Robyn L Shea, Gail Gardner, Darren Murray, Nadia Yousaf, Shaman Jhanji, Kate Tatham, David Cunningham, Nicholas Van As, Kate Young, Andrew J S Furness, Lisa Pickering, Rupert Beale, Charles Swanton, Sonia Gandhi, Steve Gamblin, David L V Bauer, George Kassiotis, Michael Howell, Emma Nicholson, Susanna Walker, James Larkin, Samra Turajlic; CAPTURE consortium
The Lancet - Omicron neutralising antibodies after COVID-19 vaccination in haemodialysis patients
Edward J Carr, Mary Wu, Ruth Harvey, Roseanne E Billany, Emma C Wall, Gavin Kelly; Haemodialysis COVID- Consortium, Crick COVID Immunity Pipeline; Michael Howell, George Kassiotis, Charles Swanton, Sonia Gandhi, David Lv Bauer, Matthew Pm Graham-Brown, Rachel B Jones, Rona M Smith, Stephen McAdoo, Michelle Willicombe, Rupert Beale
The Lancet - Three-dose vaccination elicits neutralising antibodies against omicron
Mary Wu, Emma C Wall, Edward J Carr, Ruth Harvey, Hermaleigh Townsley, Harriet V Mears, Lorin Adams, Svend Kjaer, Gavin Kelly, Scott Warchal, Chelsea Sawyer, Caitlin Kavanagh, Christophe J Queval, Yenting Ngai, Emine Hatipoglu, Karen Ambrose, Steve Hindmarsh, Rupert Beale, Steve Gamblin, Michael Howell, George Kassiotis, Vincenzo Libri, Bryan Williams, Sonia Gandhi, Charles Swanton, David Lv Bauer
The Lancet - Functional profiling of long intergenic non-coding RNAs in fission yeast
Maria Rodriguez-Lopez, Shajahan Anver, Cristina Cotobal, Stephan Kamrad, Michal Malecki, Clara Correia-Melo, Mimoza Hoti, StJohn Townsend, Samuel Marguerat, Sheng Kai Pong, Mary Y Wu, Luis Montemayor, Michael Howell, Markus Ralser, Jürg Bähler
Elife - Immune responses following third COVID-19 vaccination are reduced in patients with hematological malignancies compared to patients with solid cancer
Annika Fendler, Scott T C Shepherd, Lewis Au, Katalin A Wilkinson, Mary Wu, Andreas M Schmitt, Zayd Tippu, Sheima Farag, Aljosja Rogiers, Ruth Harvey, Eleanor Carlyle, Kim Edmonds, Lyra Del Rosario, Karla Lingard, Mary Mangwende, Lucy Holt, Hamid Ahmod, Justine Korteweg, Tara Foley, Taja Barber, Andrea Emslie-Henry, Niamh Caulfield-Lynch, Fiona Byrne, Benjamin Shum, Camille L Gerard, Daqi Deng, Svend Kjaer, Ok-Ryul Song, Christophe Queval, Caitlin Kavanagh, Emma C Wall, Edward J Carr, Sina Namjou, Simon Caidan, Mike Gavrielides, James I MacRae, Gavin Kelly, Kema Peat, Denise Kelly, Aida Murra, Kayleigh Kelly, Molly O'Flaherty, Robyn L Shea, Gail Gardner, Darren Murray, Nadia Yousaf, Shaman Jhanji, Nicholas Van As, Kate Young, Andrew J S Furness, Lisa Pickering, Rupert Beale, Charles Swanton; Crick COVID consortium; Sonia Gandhi, Steve Gamblin, David L V Bauer, George Kassiotis, Michael Howell, Emma Nicholson, Susanna Walker, Robert J Wilkinson, James Larkin, Samra Turajlic; CAPTURE consortium
Cancer Cell - Neutralising antibodies after COVID-19 vaccination in UK haemodialysis patients
Edward J Carr, Mary Wu, Ruth Harvey, Emma C Wall, Gavin Kelly, Saira Hussain, Michael Howell, George Kassiotis, Charles Swanton, Sonia Gandhi, David Lv Bauer ; Haemodialysis COVID- consortium; Crick COVID Immunity Pipeline; Roseanne E Billany, Matthew Pm Graham-Brown, Joseph Beckett, Katherine Bull, Sushma Shankar, Scott Henderson, Reza Motallebzadeh, Alan D Salama, Lorraine Harper, Patrick B Mark, Stephen McAdoo, Michelle Willicombe, Rupert Beale
The Lancet - Reduced antibody cross-reactivity following infection with B.1.1.7 than with parental SARS-CoV-2 strains
Nikhil Faulkner, Kevin W Ng, Mary Y Wu, Ruth Harvey, Marios Margaritis, Stavroula Paraskevopoulou, Catherine Houlihan, Saira Hussain, Maria Greco, William Bolland, Scott Warchal, Judith Heaney, Hannah Rickman, Moria Spyer, Daniel Frampton, Matthew Byott, Tulio de Oliveira, Alex Sigal, Svend Kjaer, Charles Swanton, Sonia Gandhi, Rupert Beale, Steve J Gamblin, John W McCauley, Rodney Stuart Daniels, Michael Howell, David Bauer, Eleni Nastouli, George Kassiotis
Elife - Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of Nsp14 RNA cap methyltransferase
Souradeep Basu, Tiffany Mak, Rachel Ulferts, Mary Wu, Tom Deegan, Ryo Fujisawa, Kang Wei Tan, Chew Theng Lim, Clovis Basier, Berta Canal, Joseph F. Curran, Lucy S. Drury, Allison W. McClure, Emma L. Roberts, Florian Weissmann, Theresa U. Zeisner, Rupert Beale, Victoria H. Cowling, Michael Howell, Karim Labib, John F.X. Diffley
Biochemical Journal - Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of Nsp5 main protease
Jennifer C Milligan, Theresa U Zeisner, George Papageorgiou, Dhira Joshi, Christelle Soudy, Rachel Ulferts, Mary Wu, Chew Theng Lim, Kang Wei Tan, Florian Weissmann, Berta Canal, Ryo Fujisawa, Tom Deegan, Hema Nagaraj, Ganka Bineva-Todd, Clovis Basier, Joseph F Curran, Michael Howell, Rupert Beale, Karim Labib, Nicola O'Reilly, John F X Diffley
Biochemical Journal - Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp14/nsp10 exoribonuclease
Berta Canal, Allison W McClure, Joseph F Curran, Mary Wu, Rachel Ulferts, Florian Weissmann, Jingkun Zeng, Agustina P Bertolin, Jennifer C Milligan, Souradeep Basu, Lucy S Drury, Tom D Deegan, Ryo Fujisawa, Emma L Roberts, Clovis Basier, Karim Labib, Rupert Beale, Michael Howell, John F X Diffley
Biochemical Journal - Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of Nsp3 papain-like protease
Chew Theng Lim, Kang Wei Tan, Mary Wu, Rachel Ulferts, Lee A Armstrong, Eiko Ozono, Lucy S Drury, Jennifer C Milligan, Theresa U Zeisner, Jingkun Zeng, Florian Weissmann, Berta Canal, Ganka Bineva-Todd, Michael Howell, Nicola O'Reilly, Rupert Beale, Yogesh Kulathu , Karim Labib, John FX Diffley
Biochemical Journal - Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp12/7/8 RNA-dependent RNA polymerase
Agustina P Bertolin, Florian Weissmann, Jingkun Zeng, Viktor Posse, Jennifer C Milligan, Berta Canal, Rachel Ulferts, Mary Wu , Lucy S Drury, Michael Howell, Rupert Beale, John F X Diffley
Biochemical Journal - Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp13 helicase
Jingkun Zeng, Florian Weissmann, Agustina P Bertolin, Viktor Posse, Berta Canal, Rachel Ulferts, Mary Wu, Ruth Harvey, Saira Hussain, Jennifer C Milligan, Chloe Roustan, Annabel Borg, Laura McCoy, Lucy S Drury, Svend Kjaer, John McCauley, Michael Howell, Rupert Beale, John F X Diffley
Biochemical Journal - AZD1222-induced neutralising antibody activity against SARS-CoV-2 Delta VOC
Emma C Wall, Mary Wu, Ruth Harvey, Gavin Kelly, Scott Warchal, Chelsea Sawyer, Rodney Daniels, Lorin Adams, Philip Hobson, Emine Hatipoglu, Yenting Ngai, Saira Hussain, Karen Ambrose, Steve Hindmarsh, Rupert Beale, Andrew Riddell, Steve Gamblin, Michael Howell, George Kassiotis, Vincenzo Libri, Bryan Williams, Charles Swanton, Sonia Gandhi, David Lv Bauer
The Lancet - Inherited duplications of PPP2R3B predispose to nevi and melanoma via a C21orf91-driven proliferative phenotype
Satyamaanasa Polubothu, Davide Zecchin, Lara Al-Olabi, Daniël A Lionarons, Mark Harland, Stuart Horswell, Anna C Thomas, Lilian Hunt, Nathan Wlodarchak, Paula Aguilera, Sarah Brand, Dale Bryant, Cristina Carrera, Hui Chen, Greg Elgar, Catherine A Harwood, Michael Howell, Lionel Larue, Sam Loughlin, Jeff MacDonald, Josep Malvehy, Sara Martin Barberan, Vanessa Martins da Silva, Miriam Molina, Deborah Morrogh, Dale Moulding, Jérémie Nsengimana, Alan Pittman, Joan-Anton Puig-Butillé, Kiran Parmar, Neil J Sebire, Stephen Scherer, Paulina Stadnik, Philip Stanier, Gemma Tell, Regula Waelchli, Mehdi Zarrei, Susana Puig, Véronique Bataille, Yongna Xing, Eugene Healy, Gudrun E Moore, Wei-Li Di, Julia Newton-Bishop, Julian Downward, Veronica A Kinsler
Genetics in Medicine - SARS-CoV-2 detection by a clinical diagnostic RT-LAMP assay
Michael D Buck, Enzo Z Poirier, Ana Cardoso, Bruno Frederico, Johnathan Canton, Sam Barrell, Rupert Beale, Richard Byrne, Simon Caidan, Margaret Crawford, Laura Cubitt, Sonia Gandhi, Robert Goldstone, Paul R Grant, Kiran Gulati, Steve Hindmarsh, Michael Howell, Michael Hubank, Rachael Instrell, Ming Jiang, George Kassiotis, Wei-Ting Lu, James I MacRae, Iana Martini, Davin Miller, David Moore, Eleni Nastouli, Jerome Nicod, Luke Nightingale, Jessica Olsen, Amin Oomatia, Nicola O'Reilly, Anett Rideg, Ok-Ryul Song, Amy Strange, Charles Swanton, Samra Turajlic, Mary Wu, Caetano Reis e Sousa; Crick COVID-19 Consortium
Wellcome Open Research - Neutralising antibody activity against SARS-CoV-2 VOCs B.1.617.2 and B.1.351 by BNT162b2 vaccination
Emma C Wall, Mary Wu, Ruth Harvey, Gavin Kelly, Scott Warchal, Chelsea Sawyer, Rodney Daniels, Philip Hobson, Emine Hatipoglu, Yenting Ngai, Saira Hussain, Jerome Nicod, Robert Goldstone, Karen Ambrose, Steve Hindmarsh, Rupert Beale, Andrew Riddell, Steve Gamblin, Michael Howell, George Kassiotis, Vincenzo Libri, Bryan Williams, Charles Swanton, Sonia Gandhi, David Lv Bauer
The Lancet - Induction of APOBEC3 Exacerbates DNA Replication Stress and Chromosomal Instability in Early Breast and Lung Cancer Evolution
Subramanian Venkatesan, Mihaela Angelova, Clare Puttick, Haoran Zhai, Deborah R Caswell, Wei-Ting Lu, Michelle Dietzen, Panagiotis Galanos, Konstantinos Evangelou, Roberto Bellelli, Emilia L Lim, Thomas B K Watkins, Andrew Rowan, Vitor H Teixeira, Yue Zhao, Haiquan Chen, Bryan Ngo, Lykourgos-Panagiotis Zalmas, Maise Al Bakir, Sebastijan Hobor, Eva Grönroos, Adam Pennycuick, Ersilia Nigro, Brittany B Campbell, William L Brown, Ayse U Akarca, Teresa Marafioti, Mary Y Wu, Michael Howell, Simon J Boulton, Cosetta Bertoli, Tim R Fenton, Robertus A M de Bruin, Apolinar Maya-Mendoza, Eric Santoni-Rugiu, Robert E Hynds, Vassilis G Gorgoulis, Mariam Jamal-Hanjani, Nicholas McGranahan, Reuben S Harris, Sam M Janes, Jirina Bartkova, Samuel F Bakhoum, Jiri Bartek, Nnennaya Kanu, Charles Swanton; TRACERx Consortium
Cancer Discovery - Estimating the effectiveness of routine asymptomatic PCR testing at different frequencies for the detection of SARS-CoV-2 infections
Joel Hellewell, Timothy W. Russell, The SAFER Investigators and Field Study Team, The Crick COVID-19 Consortium, CMMID COVID-19 working group, Rupert Beale, Gavin Kelly, Catherine Houlihan, Eleni Nastouli & Adam J. Kucharski
BMC Medicine - Disruption of the MSL complex inhibits tumour maintenance by exacerbating chromosomal instability
Josep Monserrat, Cristina Morales Torres, Louise Richardson, Thomas Stuart Wilson, Harshil Patel, Marie-Charlotte Domart, Stuart Horswell, Ok-Ryul Song, Ming Jiang, Margaret Crawford, Minh Bui, Yamini Dalal, Paola Scaffidi
Nature Cell Biology - Genomic epidemiology of COVID-19 in care homes in the east of England
William L Hamilton, Gerry Tonkin-Hill, Emily R Smith, Dinesh Aggarwal, Charlotte J Houldcroft, Ben Warne, Luke W Meredith, Myra Hosmillo, Aminu S Jahun, Martin D Curran, Surendra Parmar, Laura G Caller, Sarah L Caddy, Fahad A Khokhar, Anna Yakovleva, Grant Hall, Theresa Feltwell, Malte L Pinckert, Iliana Georgana, Yasmin Chaudhry, Colin S Brown, Sonia Gonçalves, Roberto Amato, Ewan M Harrison, Nicholas M Brown, Mathew A Beale, Michael Spencer Chapman , David K Jackson, Ian Johnston, Alex Alderton, John Sillitoe, Cordelia Langford, Gordon Dougan, Sharon J Peacock, Dominic P Kwiatowski, Ian G Goodfellow, M Estee Torok; COVID- Genomics Consortium UK
Elife - Clinical outcomes of COVID-19 in long-term care facilities for people with epilepsy
Simona Balestrini, Matthias J Koepp, Sonia Gandhi, Hannah M Rickman, Gee Yen Shin, Catherine F Houlihan, Jonny Anders-Cannon, Katri Silvennoinen, Fenglai Xiao, Sara Zagaglia, Kirsty Hudgell, Mariusz Ziomek, Paul Haimes, Adam Sampson, Annie Parker, J Helen Cross, Rosemarie Pardington, Eleni Nastouli, Charles Swanton; Crick COVID Consortium (CCC); Josemir W Sander, Sanjay M Sisodiya
Epilepsy & Behavior - WDHD1 is essential for the survival of PTEN-inactive triple-negative breast cancer
Ayse Ertay, Huiquan Liu, Dian Liu, Ping Peng, Charlotte Hill, Hua Xiong, David Hancock, Xianglin Yuan, Marcin R. Przewloka, Mark Coldwell, Michael Howell, Paul Skipp, Rob M. Ewing, Julian Downward & Yihua Wang
Cell Death & Disease - Control of skeletal morphogenesis by the Hippo-YAP/TAZ pathway
Hannah K Vanyai, Fabrice Prin, Oriane Guillermin, Bishara Marzook, Stefan Boeing, Alexander Howson, Rebecca E Saunders, Thomas Snoeks, Michael Howell, Timothy J Mohun, Barry Thompson
Development - Combined targeting of G protein-coupled receptor and EGF receptor signaling overcomes resistance to PI3K pathway inhibitors in PTEN-null triple negative breast cancer
Davide Zecchin, Christopher Moore, Fanourios Michailidis, Stuart Horswell, Sareena Rana, Michael Howell, Julian Downward
EMBO Mol Med. - Pandemic peak SARS-CoV-2 infection and seroconversion rates in London frontline health-care workers
Catherine F Houlihan, Nina Vora, Thomas Byrne, Dan Lewer, Gavin Kelly, Judith Heaney, Sonia Gandhi, Moira J Spyer, Rupert Beale, Peter Cherepanov, David Moore, Richard Gilson, Steve Gamblin, George Kassiotis, Laura E McCoy, Charles Swanton, The Crick COVID-19 Consortium, Andrew Hayward, Eleni Nastouli
The Lancet - Scalable and robust SARS-CoV-2 testing in an academic center
Jim Aitken, Karen Ambrose, Sam Barrell, Rupert Beale, Ganka Bineva-Todd, Dhruva Biswas, Richard Byrne, Simon Caidan, Peter Cherepanov, Laura Churchward, Graham Clark, Margaret Crawford, Laura Cubitt, Vicky Dearing, Christopher Earl, Amelia Edwards, Chris Ekin, Efthymios Fidanis, Alessandra Gaiba, Steve Gamblin, Sonia Gandhi, Jacki Goldman, Robert Goldstone, Paul R. Grant, Maria Greco, Judith Heaney, Steve Hindmarsh, Catherine F. Houlihan, Michael Howell, Michael Hubank, Deborah Hughes, Rachael Instrell, Deborah Jackson, Mariam Jamal-Hanjani, Ming Jiang, Mark Johnson, Leigh Jones, Nnennaya Kanu, George Kassiotis, Stuart Kirk, Svend Kjaer, Andrew Levett, Lisa Levett, Marcel Levi, Wei-Ting Lu, James I. MacRae, John Matthews, Laura E. McCoy, Catherine Moore, David Moore, Eleni Nastouli, Jerome Nicod, Luke Nightingale, Jessica Olsen, Nicola O’Reilly, Amar Pabari, Venizelos Papayannopoulos, Namita Patel, Nigel Peat, Marc Pollitt, Peter Ratcliffe, Caetano Reis e Sousa, Annachiara Rosa, Rachel Rosenthal, Chloe Roustan, Andrew Rowan, Gee Yen Shin, Daniel M. Snell, Ok-Ryul Song, Moira J. Spyer, Amy Strange, Charles Swanton, James M. A. Turner, Melanie Turner, Andreas Wack, Philip A. Walker, Sophia Ward, Wai Keong Wong, Joshua Wright, Mary Wu & The Crick COVID-19 Consortium
Nature Biotechnology - GATA3 Mediates a Fast, Irreversible Commitment to BMP4-Driven Differentiation in Human Embryonic Stem Cells
Alexandra Gunne-Braden, Adrienne Sullivan, Borzo Gharibi, Rahuman S.M. Sheriff, Alok Maity, Yi-Fang Wang, Amelia Edwards, Ming Jiang, Michael Howell, Robert Goldstone, Roy Wollman, Philip East, Silvia D.M. Santos
Cell Stem Cell - Selective inhibition of cancer cell self-renewal through a Quisinostat-histone H1.0 axis
Cristina Morales Torres , Mary Y Wu , Sebastijan Hobor , Elanor N Wainwright , Matthew J Martin, Harshil Patel, William Grey, Eva Grönroos, Steven Howell, Joana Carvalho, Ambrosius P Snijders, Michael Bustin, Dominique Bonnet, Paul D Smith, Charles Swanton, Michael Howell, Paola Scaffidi
Nature Communications - MDH1 and MPP7 Regulate Autophagy in Pancreatic Ductal Adenocarcinoma.
New M, Van Acker T, Sakamaki JI, Jiang M, Saunders RE, Long J, Wang VM, Behrens A, Cerveira J, Sudhakar P, Korcsmaros T, Jefferies HBJ, Ryan KM, Howell M, Tooze SA.
Cancer Res. 79:1884-1898 - Defining host-pathogen interactions employing an artificial intelligence workflow.
Fisch D, Yakimovich A, Clough B, Wright J, Bunyan M, Howell M, Mercer J, Frickel E.
Elife. 2019 Feb 12;8 - Identification and Validation of Novel Autophagy Regulators Using an Endogenous Readout siGENOME Screen.
New M, Van Acker T, Jiang M, Saunders R, Long JS, Sakamaki JI, Ryan KM, Howell M, Tooze SA.
Methods Mol Biol 1880:359-374. - A genome-wide RNAi screen identifies the SMC5/6 complex as a non-redundant regulator of a Topo2a-dependent G2 arrest.
Deiss K, Lockwood N, Howell M, Segeren HA, Saunders RE, Chakravarty P, Soliman TN, Martini S, Rocha N, Semple R, Zalmas LP, Parker PJ.
Nucleic Acids Res. 47:2906-2921 - The Dynamics of TGF-β Signaling Are Dictated by Receptor Trafficking via the ESCRT Machinery.
Miller DSJ, Bloxham RD, Jiang M, Gori I, Saunders RE, Das D, Chakravarty P, Howell M, Hill CS.
Cell Rep 25:1841-1855 - Quantitative Analysis Reveals that Actin and Src-Family Kinases Regulate Nuclear YAP1 and Its Export.
Ege N, Dowbaj AM, Jiang M, Howell M, Hooper S, Foster C, Jenkins RP, Sahai E.
Cell Syst. 6:692-708.e13 - The glutathione redox system is essential to prevent ferroptosis caused by impaired lipid metabolism in clear cell renal cell carcinoma.
Miess H, Dankworth B, Gouw AM, Rosenfeldt M, Schmitz W, Jiang M, Saunders B, Howell M, Downward J, Felsher DW, Peck B, Schulze A.
Oncogene 37:5435-5450 - Actomyosin drives cancer cell nuclear dysmorphia and threatens genome stability.
Takaki T, Montagner M, Serres MP, Le Berre M, Russell M, Collinson L, Szuhai K, Howell M, Boulton SJ, Sahai E, Petronczki M.
Nat Commun. 8:16013 - Cytoplasmic ATR Activation Promotes Vaccinia Virus Genome Replication.
Postigo A, Ramsden AE, Howell M, Way M.
Cell Rep 19:1022-1032 - UV Irradiation Induces a Non-coding RNA that Functionally Opposes the Protein Encoded by the Same Gene.
Williamson L, Saponaro M, Boeing S, East P, Mitter R, Kantidakis T, Kelly GP, Lobley A, Walker J, Spencer-Dene B, Howell M, Stewart A, Svejstrup JQ.
Cell 168:843-855 - APC/C Dysfunction Limits Excessive Cancer Chromosomal Instability.
Sansregret L, Patterson JO, Dewhurst S, López-García C, Koch A, McGranahan N, Chao WCH, Barry DJ, Rowan A, Instrell R, Horswell S, Way M, Howell M, Singleton MR, Medema RH, Nurse P, Petronczki M Swanton C
7:218-233 - Multiomic Analysis of the UV-Induced DNA Damage Response.
Boeing S, Williamson L, Encheva V, Gori I, Saunders RE, Instrell R, Aygün O, Rodriguez-Martinez M, Weems JC, Kelly GP, Conaway JW, Conaway RC, Stewart A, Howell M, Snijders AP, Svejstrup JQ.
Cell Rep. 2016 S2211-1247 - Inhibition of fatty acid desaturation is detrimental to cancer cell survival in metabolically compromised environments.
Peck B, Schug ZT, Zhang Q, Dankworth B, Jones DT, Smethurst E, Patel R, Mason S, Jiang M, Saunders R, Howell M, Mitter R, Spencer-Dene B, Stamp G, McGarry L, James D, Shanks E, Aboagye E, Critchlow SE, Leung HY, Harris AL, Wakelam MJ, Gottlieb E, Schulze A
Cancer Metab. 4:6 - Knockout of the PKN Family of Rho Effector Kinases Reveals a Non-redundant Role for PKN2 in Developmental Mesoderm Expansion.
Quétier I, Marshall JJ, Spencer-Dene B, Lachmann S, Casamassima A, Franco C, Escuin S, Worrall JT, Baskaran P, Rajeeve V, Howell M, Copp AJ, Stamp G, Rosewell I, Cutillas P, Gerhardt H, Parker PJ, Cameron AJ
Cell Rep 14(3):440-8 - The sorting protein PACS-2 promotes ErbB signalling by regulating recycling of the metalloproteinase ADAM17.
Dombernowsky SL, Samsoe-Petersen J, Petersen CH, Instrell R, Hedegaard AM, Thomas L, Atkins KM, Auclair S, Albrechtsen R, Mygind KJ, Frohlich C, Howell M, Parker P, Thomas G, Kveiborg M.
- Functional screening identifies MCT4 as a key regulator of breast cancer cell metabolism and survival.
Baenke F, Dubuis S, Brault C, Weigelt B, Dankworth B, Griffiths B, Jiang M, Mackay A, Saunders B, Spencer-Dene B, Ros S, Stamp G, Reis-Filho JS, Howell M, Zamboni N, Schulze A.
J Pathol. 2015 May 12. doi: 10.1002/path.4562. - High-throughput screening approaches to identify regulators of mammalian autophagy.
Joachim J, Jiang M, McKnight NC, Howell M, Tooze SA.
Methods. 2015 75:96-104. - Acetyl-CoA synthetase 2 promotes acetate utilization and maintains cancer cell growth under metabolic stress.
Schug ZT, Peck B, Jones DT, Zhang Q, Grosskurth S, Alam IS, Goodwin LM, Smethurst E, Mason S, Blyth K, McGarry L, James D, Shanks E, Kalna G, Saunders RE, Jiang M, Howell M, Lassailly F, Thin MZ, Spencer-Dene B, Stamp G, van den Broek NJ, Mackay G, Bulusu
Cancer Cell. 2015 27:57-71 - Functional genomics identifies a requirement of pre-mRNA splicing factors for sister chromatid cohesion.
Sundaramoorthy S, Vazquez-Novelle MD, Lekomtsev S, Howell M, Petronczki M.
EMBO J. 2014 33(22):2623-42 - Chromosomal instability selects gene copy-number variants encoding core regulators of proliferation in ER+ breast cancer.
Endesfelder D, Burrell RA, Kanu N, McGranahan N, Howell M, Parker PJ, Downward J, Swanton C, Kschischo M.
Cancer Res. 2014 74(17):4853-63. - Ccdc13 is a novel human centriolar satellite protein required for ciliogenesis and genome stability.
Staples CJ, Myers KN, Beveridge RD, Patil AA, Howard AE, Barone G, Lee AJ, Swanton C, Howell M, Maslen S, Skehel JM, Boulton SJ, Collis SJ.
J Cell Sci. 2014;127(Pt 13):2910-9. - Reduced NF1 expression confers resistance to EGFR inhibition in lung cancer.
de Bruin EC, Cowell C, Warne PH, Jiang M, Saunders RE, Melnick MA, Gettinger S, Walther Z, Wurtz A, Heynen GJ, Heideman DA, Gomez-Roman J, Garcia-Castano A, Gong Y, Ladanyi M, Varmus H, Bernards R, Smit EF, Politi K, Downward J.
Cancer Discov. 2014 4:606-19. - Salt-inducible kinases regulate growth through the Hippo signalling pathway in Drosophila.
Wehr MC, Holder MV, Gailite I, Saunders RE, Maile TM, Ciirdaeva E, Instrell R, Jiang M, Howell M, Rossner MJ, Tapon N.
Nature Cell Biology 2013:15:61-71 - Affordable Luciferase Reporter Assay for Cell-Based High-Throughput Screening.
Siebring-van Olst E, Vermeulen C, de Menezes RX, Howell M, Smit EF, van Beusechem VW.
J Biomol Screen. 2012 Oct 30 - The centriolar satellite protein Cep131 is important for genome stability.
Staples CJ, Myers KN, Beveridge RD, Patil AA, Lee AJ, Swanton C, Howell M, Boulton SJ, Collis SJ.
J Cell Sci. 2012 Jul 13. - Determination of synthetic lethal interactions in KRAS oncogene-dependent cancer cells reveals novel therapeutic targeting strategies.
Steckel M, Molina-Arcas M, Weigelt B, Marani M, Warne PH, Kuznetsov H, Kelly G, Saunders B, Howell M, Downward J, Hancock DC.
Cell Res. 2012 22:1227-45 - Functional metabolic screen identifies 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 as an important regulator of prostate cancer cell survival.
Ros S, Santos CR, Moco S, Baenke F, Kelly G, Howell M, Zamboni N, Schulze A.
Cancer Discov. 2012 2:328-43 - Binding of dynein intermediate chain 2 to paxillin controls focal adhesion dynamics and migration
Rosse C, Boeckeler K, Linch M, Radtke S, Frith D, Barnouin K, Morsi AS, Hafezparast M, Howell M, Parker PJ.
J Cell Sci. 2012125:3733-8 - Genome-wide RNA interference analysis of renal carcinoma survival regulators identifies MCT4 as a Warburg effect metabolic target.
Gerlinger M, Santos CR, Spencer-Dene B, Martinez P, Endesfelder D, Burrell RA, Vetter M, Jiang M, Saunders RE, Kelly G, Dykema K, Rioux-Leclercq N, Stamp G, Patard JJ, Larkin J, Howell M, Swanton C.
J Pathol. 2012 227:146-56 - Genome-wide siRNA screen reveals amino acid starvation-induced autophagy requires SCOC and WAC.
McKnight NC, Jefferies HB, Alemu EA, Saunders RE, Howell M, Johansen T, Tooze SA.
EMBO J. 2012 31:1931-46 - Tales from an academic RNAi screening facility; FAQs.
Jiang M, Instrell R, Saunders B, Berven H, Howell M.
Brief Funct Genomics. 2011 10:227-37 - Anomalous inhibition of c-Met by the kinesin inhibitor aurintricarboxylic acid
Milanovic M, Radtke S, Peel N, Howell M, Carriere V, Joffre C, Kermorgant S, Parker PJ.
Int J Cancer. 2012 130:1060-70 - PKCa and PKCd regulate ADAM17-mediated ectodomain shedding of heparin binding-EGF through separate pathways.
Kveiborg M, Instrell R, Rowlands C, Howell M, Parker PJ.
PLoS One. 2011 6:e17168. - Chromosomal instability confers intrinsic multidrug resistance.
Lee AJ, Endesfelder D, Rowan AJ, Walther A, Birkbak NJ, Futreal PA, Downward J, Szallasi Z, Tomlinson IP, Howell M, Kschischo M, Swanton C.
Cancer Res. 2011 71:1858-70. - Combined functional genomic and proteomic approaches identify a PP2A complex as a negative regulator of Hippo signaling.
Ribeiro PS, Josue F, Wepf A, Wehr MC, Rinner O, Kelly G, Tapon N, Gstaiger M.
Mol Cell. 2010 39:521-34. - Predictive biomarker discovery through the parallel integration of clinical trial and functional genomics datasets.
Swanton C, Larkin JM, Gerlinger M, Eklund AC, Howell M, Stamp G, Downward J, Gore M, Futreal PA, Escudier B, Andre F, Albiges L, Beuselinck B, Oudard S, Hoffmann J, Gyorffy B, Torrance CJ, Boehme KA, Volkmer H, Toschi L, Nicke B, Beck M, Szallasi Z.
Genome Med. 2010 2:53. - Manipulating signal delivery - plasma-membrane ERK activation in aPKC-dependent migration
Boeckeler K, Rosse C, Howell M, Parker PJ.
J Cell Sci. 2010 123:2725-32 - Nuclear import impairment causes cytoplasmic trans-activation response DNA-binding protein accumulation and is associated with frontotemporal lobar degeneration.
Nishimura AL, Zupunski V, Troakes C, Kathe C, Fratta P, Howell M, Gallo JM, Hortobagyi T, Shaw CE, Rogelj B.
Brain. 2010 133:1763-71 - Chromosomal instability determines taxane response.
Swanton C, Nicke B, Schuett M, Eklund AC, Ng C, Li Q, Hardcastle T, Lee A, Roy R, East P, Kschischo M, Endesfelder D, Wylie P, Kim SN, Chen JG, Howell M, Ried T, Habermann JK, Auer G, Brenton JD, Szallasi Z, Downward J.
Proc Natl Acad Sci U S A. 2009 106:8671-6 - siRNA screening of the kinome identifies ULK1 as a multi-domain modulator of autophagy.
Chan EY, Kir S, Tooze SA.
J Biol Chem. 2007 282:25464-74 - Arkadia activates Smad3/Smad4-dependent transcription by triggering signal-induced SnoN degradation.
Levy L, Howell M, Das D, Harkin S, Episkopou V, Hill CS.
Mol Cell Biol. 2007 27:6068-83. - Regulators of mitotic arrest and ceramide metabolism are determinants of sensitivity to paclitaxel and other chemotherapeutic drugs.
Swanton C, Marani M, Pardo O, Warne PH, Kelly G, Sahai E, Elustondo F, Chang J, Temple J, Ahmed AA, Brenton JD, Downward J, Nicke B.
Cancer Cell 2007 11:498-512.