| Project Overview: | Autophagy is important for cell survival. Autophagy is induced in many pathological conditions, but the best characterized response is in conditions of amino acid deprivation. Induction of autophagy results in portions of the cell cytoplasm and intracellular organelles being sequestered inside membrane-bound vesicles, autophagosomes. Autophagosomes fuse with the endosome/lysosome and become degradative, thus allowing the sequested proteins to be degraded to amino acids to re-supply the cell. My lab is interested in understanding the origins of the autophagosome, and the signalling pathways which lead to the formation of these membranes. Our current information about this process is sparse, and the identification of new candidates which are involved in the process, or in the regulation of the process would be a significant contribution to the field, and an important advance for my lab. |
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| Screener: | Nicole McKnight (Tooze Lab). Extension:3145, Rm 612 |
| Project Status: | Published |
| Publications: | Genome-wide siRNA screen reveals amino acid starvation-induced autophagy requires SCOC and WAC.. McKnight et al., 2012 |
| Project Start Date: | Apr 2008 |
| Keywords: | Amino acid deprivation Autophagosome Autophagy |
| Hits: | NM_016628 - Amino acid starvation-induced autophagy requires WAC NM_032547 - Amino acid starvation-induced autophagy requires SCOC |
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