| Project Overview: | The Hippo (Hpo) pathway is a central determinant of tissue size in both Drosophila and higher organisms.The core of the pathway is a kinase cascade composed of an upstream kinase Hpo (MST1/2 in mammals) and a downstream kinase Warts (Wts,Lats1/2 in mammals), as well as several scaffold proteins, Sav, dRASSF, and Mats. Activation of the core kinase cassette results in phosphorylation and in activation of the progrowth transcriptional co-activator Yki, leading to increased apoptosis and reduced tissue growth. The mechanisms that prevent inappropriate Hpo activation remain unclear, and in particular,the identity of the phosphatase that antagonizes Hpo is unknown |
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| Screener: | Filipe Josue (Tapon Lab). Extension:3661, Rm 230 |
| Project Status: | Published |
| Publications: | Combined functional genomic and proteomic approaches identify a PP2A complex as a negative regulator of Hippo signaling.. Ribeiro, Josue et al., 2010 |
| Project Start Date: | Oct 2007 |
| Keywords: | Hippo signaling |
| Libraries Screened: |
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