| Project Overview: | Cytokinesis is the final step of cell division and forms the basis for cell multiplication on our planet. The primary goal of our project is to use available functional genomic data to identify novel regulators of cytokinesis in human cells. Using a list of candidate genes emerging from the published screens as a starting point, we try to decipher the role of individual proteins in initiating, conducting and exiting the process of cell division. Secondary screens and further characterization have managed to provide us with candidates for cytokinesis regulators with interesting phenotypes. We are now in the process of verifying whether the depletion of intended target gene is linked to the observed defect or if it is an off target effect. |
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| Screener: | Ram Sundaramoorthy (Petronczki Lab). Extension:5628, Rm B24 |
| Project Status: | Published |
| Publications: | Functional genomics identifies a requirement of pre-mRNA splicing factors for sister chromatid cohesion.. Sundaramoorthy et al., 2014 |
| Project Start Date: | Feb 2009 |
| Keywords: | Cytokinesis |
| Libraries Screened: |
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